Left ventricular functional changes after adenosine vasodilator stress evaluated by gated single-photon emission
Ling Zhang1, Yue-Qin Tian, Xiao-Li Zhang
1Department of Nuclear Medicine, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, PR China.
Cardiology
|May 29, 2013
Summary
Worsening left ventricular ejection fraction (LVEF) after adenosine stress indicates significant coronary artery disease (CAD). Gated SPECT reveals this functional change as a key nonperfusion marker for CAD.
Area of Science:
- Cardiology
- Nuclear Medicine
- Diagnostic Imaging
Background:
- Gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging assesses left ventricular (LV) function.
- Adenosine vasodilator stress is commonly used in SPECT myocardial perfusion imaging.
Purpose of the Study:
- To evaluate LV functional changes after adenosine vasodilator stress using gated SPECT.
- To identify nonperfusion markers of significant coronary artery disease (CAD).
Main Methods:
- Seventy patients underwent adenosine stress and rest SPECT, along with coronary angiography.
- Semi-quantitative perfusion assessment (SRS, SSS, SDS) and LV function (EF, EDV, ESV, SMS, STS) were quantified by gated SPECT.
Main Results:
- Patients were grouped by LVEF change after adenosine stress (Group 1: worsening LVEF; Group 2: no worsening).
- Group 1 showed significantly higher summed stress score (SSS) and summed difference score (SDS), indicating more severe stenosis and perfusion defects.
Conclusions:
- Worsening LVEF after adenosine stress is a valuable nonperfusion marker of significant CAD.
- (99m)Tc-MIBI gated SPECT can detect these functional changes, aiding in CAD diagnosis.
