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Related Experiment Video

Updated: May 11, 2026

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
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Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

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Hyperprolactinemia impairs object recognition without altering spatial learning in male rats.

Luz Torner1, Eréndira Tinajero, Naima Lajud

  • 1Centro de Investigación Biomédica de Michoacán, Instituto Mexicano del Seguro Social, Morelia, Michoacán, Mexico. luz_torner@yahoo.com

Behavioural Brain Research
|May 29, 2013
PubMed
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High prolactin (PRL) levels impair object recognition memory in rats, but do not affect spatial learning abilities. This suggests prolactin influences non-spatial cognitive functions.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Cognitive Psychology

Background:

  • Prolactin (PRL) is known to protect the hippocampus from stress and neurotoxins.
  • PRL-deficient mice exhibit learning and memory deficits, suggesting the hippocampus is a PRL target.
  • Previous research indicates a potential role for PRL in hippocampal function and cognitive processes.

Purpose of the Study:

  • To investigate the functional impact of serum prolactin concentrations on hippocampal formation.
  • To determine if varying prolactin levels affect spatial learning, memory retrieval, and object recognition.
  • To elucidate the role of prolactin in modulating non-spatial cognitive tasks.

Main Methods:

  • Male Sprague-Dawley rats were used, with groups receiving pituitary homografts (HPRL) to increase PRL or bromocriptine (BRC) to decrease PRL.
Keywords:
BromocriptineCognitionFamiliarityHippocampusMorris water mazeProlactin

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Last Updated: May 11, 2026

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  • Control groups included sham operation (SHAM) and vehicle (VEH) administration.
  • Cognitive functions were assessed using the Morris water maze (MWM), object recognition test, and elevated plus maze (EPM).
  • Serum PRL concentrations were quantified using ELISAs.

    • Main Results:

    • No significant differences in spatial learning or memory retrieval were observed in the MWM between HPRL and SHAM, or BRC and VEH groups.
    • Rats with high prolactin levels (HPRL) showed impaired object recognition, failing to discriminate novel from familiar objects.
    • Bromocriptine treatment (BRC) reduced object exploration but did not significantly alter the discrimination index compared to controls.
    • No significant differences in anxiety-like behavior were found in the EPM.

    Conclusions:

    • Elevated prolactin levels specifically impair object recognition memory in rats.
    • Prolactin does not appear to affect spatial learning or memory retrieval abilities.
    • These findings demonstrate that prolactin modulates non-spatial cognitive functions, particularly object recognition.