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Impaired renal function is a major determinant of left ventricular diastolic dysfunction: assessment by stress

Wakana Sato1, Toshimitsu Kosaka, Takashi Koyama

  • 1Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan, wsato@med.akita-u.ac.jp.

Annals of Nuclear Medicine
|May 29, 2013
PubMed

Insights

Impaired kidney function significantly impacts left ventricular diastolic function in patients with suspected coronary artery disease. Lower estimated glomerular filtration rate (eGFR) is linked to poorer diastolic function, highlighting the kidney

Area of Science:

  • Cardiology
  • Nephrology
  • Nuclear Medicine

Background:

  • Renal function's impact on cardiac health is increasingly recognized.
  • Left ventricular (LV) diastolic dysfunction is a key indicator of cardiac compromise.
  • The relationship between estimated glomerular filtration rate (eGFR) and LV diastolic function requires further elucidation.

Purpose of the Study:

  • To investigate the correlation between eGFR and LV diastolic function.
  • To assess LV diastolic function using stress electrocardiographic (ECG)-gated myocardial single photon emission computed tomography (SPECT).
  • To determine if impaired renal function is a determinant of LV diastolic dysfunction in patients with suspected coronary artery disease (CAD).

Main Methods:

  • 136 patients with suspected CAD underwent technetium-99m stress ECG-gated myocardial SPECT.
  • LV diastolic function assessed via peak filling rate (PFR), 1/3 mean filling rate, and time to peak filling.
  • Patients categorized into four groups based on CAD and chronic kidney disease (CKD) status (eGFR <60 mL/min/1.73 m²).

Main Results:

  • Peak filling rate (PFR) was significantly impaired in patients with CKD and those with both CAD and CKD compared to controls.
  • PFR at rest positively correlated with eGFR and inversely correlated with summed difference score (SDS).
  • Multivariate analysis independently associated eGFR with PFR (β = 0.260, p = 0.002).

Conclusions:

  • Impaired renal function is a significant determinant of LV diastolic dysfunction.
  • Reduced eGFR is associated with impaired diastolic function in patients with suspected CAD.
  • These findings underscore the importance of assessing renal function in cardiac evaluations.
Abstract

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