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Therapeutic Potential of Modulating MicroRNA in Peripheral Artery Disease

Naomi M Hamburg1, Nicholas J Leeper

  • 1Section of Cardiology, Boston Medical Center, 88 East Newton St., Boston, MA, 02118. nhamburg@bu.edu.

Current Vascular Pharmacology
|May 30, 2013
PubMed

Insights

MicroRNAs are linked to peripheral artery disease (PAD) processes like blood vessel growth and inflammation. These molecules in circulation may offer new ways to diagnose and treat PAD lower extremity ischemia.

Area of Science:

  • Biomedical research
  • Molecular biology
  • Vascular medicine

Background:

  • Peripheral artery disease (PAD) causes significant lower extremity ischemia and disability.
  • Current treatments for PAD symptoms are limited.
  • MicroRNAs are increasingly recognized for their role in vascular health and disease.

Purpose of the Study:

  • To review the role of microRNAs in key pathogenic pathways of PAD.
  • To explore the potential of microRNAs as diagnostic biomarkers for PAD.
  • To discuss microRNA-based therapeutic strategies for PAD.

Main Methods:

  • Literature review of studies investigating microRNA involvement in PAD.
  • Analysis of microRNA's role in angiogenesis, endothelial function, inflammation, and vascular regeneration.
  • Examination of microRNAs in circulation as potential biomarkers.

Main Results:

  • MicroRNAs regulate critical processes in PAD pathogenesis, including angiogenesis, endothelial function, inflammation, and vascular smooth muscle cell function.
  • MicroRNAs are detectable in circulation, suggesting their utility as biomarkers.
  • Evidence supports microRNA's involvement in restenosis and mitochondrial dysfunction in PAD.

Conclusions:

  • MicroRNAs are integral to PAD development and progression.
  • Circulating microRNAs hold promise as non-invasive biomarkers for PAD diagnosis.
  • Targeting microRNAs may offer novel therapeutic avenues for PAD patients.

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