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Related Concept Videos

Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...

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Related Experiment Video

Updated: May 11, 2026

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
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MicroRNAs in Abdominal Aortic Aneurysm.

Matti Adam, Uwe Raaz, Joshua M Spin

  • 1Stanford University, Stanford School of Medicine, Division of Cardiovascular Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA. ptsao@stanford.edu.

Current Vascular Pharmacology
|May 30, 2013
PubMed
Summary

MicroRNAs (miRs) show promise for treating abdominal aortic aneurysms (AAA), a major cause of death. Further research is needed to explore miRs as novel therapeutic targets for vascular disease.

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Last Updated: May 11, 2026

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Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Vascular Pathobiology

Background:

  • Abdominal aortic aneurysms (AAA) are a significant cause of mortality globally.
  • Current treatments for AAA, including open surgery and endovascular repair, are limited.
  • Existing cardiovascular medications have not effectively prevented or altered AAA progression.

Purpose of the Study:

  • To review the role of microRNAs (miRs) in abdominal aortic aneurysm (AAA) formation and progression.
  • To explore the diagnostic and therapeutic potential of miRs in vascular disease.
  • To summarize recent findings on specific miRs implicated in AAA pathogenesis.

Main Methods:

  • Literature review of recent publications on miRs and AAA.
  • Analysis of known effects of specific miRs (e.g., miR-21, miR-29b) in AAA formation.
  • Identification of other miRs with potential therapeutic relevance.

Main Results:

  • Several miRs, including miR-21 and miR-29b, are implicated in AAA development.
  • Other miRs like miR-26a, miR-17-92-cluster, miRs-221/222, miR-133, and miR-146a show potential for altering AAA progression.
  • miRs regulate key cellular components involved in AAA, such as inflammatory cells, endothelial cells, smooth muscle cells, and fibroblasts.

Conclusions:

  • MicroRNAs represent a promising avenue for novel therapeutic strategies against AAA.
  • Targeting miRs could offer new diagnostic and treatment possibilities for vascular pathobiology.
  • Extensive further research is required to fully elucidate the therapeutic potential of miRs in AAA.