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Diagnostic and management strategies for donor-derived infections

Pearlie P Chong1, Raymund R Razonable

  • 1Division of Infectious Diseases, Department of Medicine, William J. von Liebig Transplant Center, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA. Chong.Pearlie@mayo.edu

Infectious Disease Clinics of North America
|May 30, 2013
PubMed

Insights

Donor-derived infections pose risks despite screening. This review covers donor evaluation, screening limits, recipient assessment, and managing these infections for physicians.

Area of Science:

  • Infectious Diseases
  • Transplantation Medicine
  • Public Health

Background:

  • Donor-derived infections remain a significant concern in organ transplantation.
  • Current screening methods for organ donors have limitations in detecting all potential infections.

Purpose of the Study:

  • To review organ donor evaluation and screening limitations.
  • To outline recipient evaluation for suspected donor-derived infections.
  • To discuss diagnostic and management strategies for selected donor-derived infections.

Main Methods:

  • Literature review of donor evaluation processes.
  • Analysis of current organ donor screening protocols.
  • Review of diagnostic and management guidelines for infections transmitted via organ donation.

Main Results:

  • Standard donor screening is insufficient to prevent all infections.
  • Prompt recipient evaluation is crucial when donor-derived infection is suspected.
  • Specific diagnostic and management approaches are necessary for different pathogens.

Conclusions:

  • Improving donor screening and recipient vigilance is essential.
  • Physicians need clear guidelines for managing donor-derived infections.
  • Further research into advanced screening may reduce transmission risks.

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