Related Experiment Video
Updated: May 11, 2026

Neurovascular Network Explorer 2.0: A Simple Tool for Exploring and Sharing a Database of Optogenetically-evoked Vasomotion in Mouse Cortex In Vivo
Published on: May 4, 2018
PDGF-C: a new performer in the neurovascular interplay
Chunsik Lee1, Fan Zhang, Zhongshu Tang
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, P.R. China.
Platelet-derived growth factor C (PDGF-C) is a key regulator of neurovascular crosstalk, distinct from vascular endothelial growth factor (VEGF). This finding introduces a new paradigm for understanding brain development and disease.
Area of Science:
- Neuroscience
- Vascular Biology
- Developmental Biology
Background:
- Neurovascular crosstalk is crucial for brain development, function, and disease.
- Vascular endothelial growth factor (VEGF) is a well-studied regulator of neurovascular interactions.
- Additional regulators of neurovascular crosstalk are needed to fully understand this process.
Purpose of the Study:
- To investigate the role of platelet-derived growth factor C (PDGF-C) in neurovascular crosstalk.
- To compare the function and expression of PDGF-C with VEGF in neurovascular interactions.
Main Methods:
- Analysis of PDGF-C expression patterns.
- Assessment of PDGF-C's angiogenic properties.
- Evaluation of PDGF-C as a neuronal survival factor.
Main Results:
- Platelet-derived growth factor C (PDGF-C) exhibits both angiogenic and neuronal survival properties.
- PDGF-C plays a significant role in neurovascular crosstalk.
- The expression and function of PDGF-C differ from those of VEGF.
Conclusions:
- PDGF-C represents an important regulator of neurovascular crosstalk.
- PDGF-C-mediated interactions may offer a novel paradigm for neurovascular crosstalk, distinct from VEGF pathways.
Related Concept Videos
Nervous Tissue: Glial Cells
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...
Neurogenesis and Regeneration of Nervous Tissue
Neural Regulation
The Blood-brain Barrier

