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Updated: May 11, 2026

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis

Published on: January 9, 2026

Aptamer-functionalized hydrogel diffraction gratings for the human thrombin detection.

Xiaoqi Wang¹, Xiaogong Wang

¹Department of Chemical Engineering, Laboratory of Advanced Materials (MOE), Tsinghua University, Beijing, PR China.

Chemical Communications (Cambridge, England)

|May 30, 2013

Summary

This summary is machine-generated.

Aptamer-functionalized hydrogel diffraction gratings were created using aptamers and complementary sequences. These novel gratings detect human thrombin via changes in diffracted light, demonstrating a sensitive biosensing capability.

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Area of Science:

Biomaterials Science
Nanotechnology
Analytical Chemistry

Background:

Hydrogels offer tunable properties for various applications.
Aptamers are short DNA or RNA sequences with high specificity for target molecules.
Diffraction gratings can be used for optical sensing applications.

Purpose of the Study:

To fabricate aptamer-functionalized hydrogel diffraction gratings.
To investigate the sensing capabilities of these gratings for human thrombin detection.

Main Methods:

Incorporation of aptamer and its complementary sequence as crosslinking junctions within the hydrogel network.
Fabrication of diffraction gratings using the aptamer-functionalized hydrogel.
Monitoring changes in diffracted light in response to human thrombin.

Main Results:

Successful fabrication of aptamer-functionalized hydrogel diffraction gratings.
Demonstrated sensitive optical response of the gratings to human thrombin.
The diffracted light signal correlated with the presence of human thrombin.

Conclusions:

Aptamer-functionalized hydrogel diffraction gratings are a viable platform for biosensing.
This approach enables sensitive and specific detection of human thrombin.
The diffracted light readout offers a non-invasive sensing mechanism.