Related Experiment Video
Updated: Jul 2, 2026
12:23
In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses
Published on: September 7, 2022
Aptamer-powered surveillance of SARS-CoV-3
Jacob Eicholtz1, Ryanna Tuttle1, Dylan Hohlfelder1
1Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA. tanx@bgsu.edu.
Chemical Communications (Cambridge, England)
|July 1, 2026
Abstract
None:
Rapid detection of emerging coronaviruses is critical for preparedness. The S2A2C1 aptamer broadly recognizes Beta-coronavirus S2 domains but not influenza proteins. A sandwich aptamer assay achieved ∼0.51 pM detection limits and functions in serum, enabling a sensitive, adaptable platform for universal coronavirus detection and real-time surveillance of emerging variants.
