Aptamer-assisted phage display: enhancing checkpoint inhibition with a peptide and an aptamer targeting distinct
Satya Prakash Arya1, Siddhartha Kalpa Samadhi Thennakoon1, Chien Minh Tran Phuoc1
1Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA. tanx@bgsu.edu.
Chemical Communications (Cambridge, England)
|June 28, 2024
Abstract:
Utilizing a novel approach known as aptamer-assisted phage display (APD), we identified an anti-PD-L1 peptide, NV Pep, capable of simultaneous binding to PD-L1 alongside the DNA aptamer MJ5C. Combined inhibition using NV Pep and MJ5C demonstrated significant enhancement compared to individual ligands against the PD-1/PD-L1 interaction.
