Multivalency amplifies the selection and affinity of bradykinin-derived peptides for lipid nanovesicles
Jonel P Saludes1, Leslie A Morton, Sara K Coulup
1Department of Chemistry & Biochemistry and BioFrontiers Institute, University of Colorado, Boulder, CO 80309, USA.
Molecular Biosystems
|May 30, 2013
Abstract:
The trimer of a bradykinin derivative displayed a more than five-fold increase in binding affinity for phosphatidylserine-enriched nanovesicles as compared to its monomeric precursor. The nanovesicle selection is directly correlated with multivalency, which amplifies the electrostatic attraction. This strategy may lead to the development of novel molecular probes for detecting highly curved membrane bilayers.
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