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Related Concept Videos

Introduction to Enzyme Kinetics01:19

Introduction to Enzyme Kinetics

Enzyme kinetics studies the rates of biochemical reactions. Scientists monitor the reaction rates for a particular enzymatic reaction at various substrate concentrations. Additional trials with inhibitors or other molecules that affect the reaction rate may also be performed.
The experimenter can then plot the initial reaction rate or velocity (Vo) of a given trial against the substrate concentration ([S]) to obtain a graph of the reaction properties. For many enzymatic reactions involving a...
Enzyme Kinetics01:19

Enzyme Kinetics

Enzymes speed up reactions by lowering the activation energy of the reactants. The speed at which the enzyme turns reactants into products is called the rate of reaction. Several factors impact the rate of reaction, including the number of available reactants. Enzyme kinetics is the study of how an enzyme changes the rate of a reaction.
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Induced-fit Model01:13

Induced-fit Model

Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical characteristics of...
Introduction to Metabolism01:30

Introduction to Metabolism

Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...

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Updated: May 11, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

Using chemical kinetics to model biochemical pathways.

Nicolas Le Novère1, Lukas Endler

  • 1Babraham Institute, Cambridge, Cambridgeshire, UK.

Methods in Molecular Biology (Clifton, N.J.)
|May 30, 2013
PubMed
Summary
This summary is machine-generated.

This chapter introduces chemical kinetics, the study of reaction rates, and its crucial role in biochemistry and systems biology. It explains how ordinary differential equations model reaction systems and regulatory networks.

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Last Updated: May 11, 2026

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Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

Area of Science:

  • Biochemistry
  • Systems Biology
  • Chemical Kinetics

Background:

  • Chemical kinetics is fundamental to understanding biochemical processes.
  • It became a cornerstone of biochemistry in the 20th century.
  • Integration with systems theory birthed systems biology.

Purpose of the Study:

  • Introduce basic concepts of chemical and enzyme kinetics.
  • Demonstrate modeling of reaction systems using ordinary differential equations.
  • Present a method for modeling regulatory networks.

Main Methods:

  • Review of fundamental chemical and enzyme kinetics principles.
  • Application of ordinary differential equations for temporal dynamics.
  • Development of a modeling approach for regulatory networks.

Main Results:

  • Provides foundational knowledge in chemical and enzyme kinetics.
  • Illustrates the use of differential equations for reaction system analysis.
  • Offers a method for modeling complex regulatory networks.

Conclusions:

  • Chemical kinetics is essential for quantitative analysis in biochemistry and systems biology.
  • Ordinary differential equations are a powerful tool for modeling dynamic biological systems.
  • The presented method facilitates the modeling of regulatory networks.