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Therapeutic effect of total ginseng saponin on skin wound healing
Young Soo Kim1, Ik-Hyun Cho, Moon-Jin Jeong
1Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine, Gwangju 500-757, Korea.
Abstract:
In this study, we investigated the effects of total ginseng saponin (TGS) on the cutaneous wound healing process using histological analysis. A total of 24 ICR mice, 5-weeks-old, were used for all in vivo experiments. Mice were divided into control and TGS-treated groups and four equidistant 1-cm full-thickness dorsal incisional wounds were created. The wounds were extracted at days 1, 3, 5, and 7 post-injury for histomorphometrical analysis including wound area and contracture measurements, keratinocyte migration rate, and calculation of infiltrating inflammatory cells. The results showed that the wound area was smaller and keratinocyte migration rate was higher in the TGS-treated group than that of the control group from days 3 to 7. Inflammatory cells in the TGS-treated group at days 1 and 3 were reduced compared to the control group. Wound contraction in the TGS-treated group was greater than in the control group on days 3 to 5, and collagen deposition in the TGS-treated group was higher than in the control group during wound healing. The results indicate a beneficial effect of TGS when used to treat skin wounds.
Insights
Total ginseng saponin (TGS) accelerates skin wound healing by reducing inflammation and increasing collagen deposition. TGS treatment led to smaller wound areas and enhanced keratinocyte migration in mice.
Area of Science:
- Dermatology
- Pharmacology
- Wound Healing Research
Background:
- Cutaneous wound healing is a complex biological process.
- Natural compounds are explored for their therapeutic potential in wound management.
- Ginseng saponins are known for various biological activities.
Purpose of the Study:
- To evaluate the efficacy of total ginseng saponin (TGS) in promoting cutaneous wound healing.
- To investigate the histological and cellular mechanisms underlying TGS's effect on skin wounds.
Main Methods:
- In vivo study using 24 ICR mice with full-thickness dorsal incisional wounds.
- Comparison between a control group and a group treated with TGS.
- Histomorphometrical analysis of wound area, contracture, keratinocyte migration, inflammatory cell infiltration, and collagen deposition at various time points (days 1, 3, 5, 7).
Main Results:
- TGS treatment resulted in significantly smaller wound areas from days 3 to 7 compared to controls.
- Enhanced keratinocyte migration rate was observed in the TGS-treated group.
- Reduced inflammatory cell infiltration was noted at days 1 and 3 post-injury.
- Increased wound contraction and collagen deposition were evident in the TGS group during the healing period.
Conclusions:
- Total ginseng saponin (TGS) demonstrates a beneficial effect on cutaneous wound healing.
- TGS promotes healing by accelerating keratinocyte migration, reducing inflammation, and enhancing tissue regeneration.
- These findings suggest TGS as a potential therapeutic agent for skin wound treatment.
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