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Related Experiment Video

Updated: May 11, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

Colorectal cancer: molecular mutations and polymorphisms.

Aga Syed Sameer¹

¹Department of Biochemistry, Sher-I-Kashmir Institute of Medical Sciences Associated Medical College, Bemina, Srinagar Kashmir, India.

Frontiers in Oncology

|May 30, 2013

Summary

Colorectal cancer (CRC) arises from chromosomal instability (CIN) or microsatellite instability (MIN) pathways. This review examines gene mutations and polymorphisms in these pathways crucial for CRC development.

Keywords:

colorectal cancer hypermethylation medical genetics mutations polymorphism

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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

Area of Science:

Oncology
Genetics
Cancer Biology

Background:

Colorectal cancer (CRC) is a leading cause of cancer-related death globally, ranking third in men and second in women.
CRC incidence varies significantly across different racial and ethnic populations.
Tumorigenesis in CRC involves chromosomal instability (CIN), microsatellite instability (MIN), genetic mutations, and epigenetic alterations.

Purpose of the Study:

To review mutations and polymorphisms in key genes within the CIN and MIN pathways.
To highlight genetic factors contributing to colorectal cancer development.

Main Methods:

Literature review focusing on genetic mutations and polymorphisms.
Analysis of genes involved in chromosomal instability (CIN) and microsatellite instability (MIN) pathways.

Main Results:

Identified critical gene mutations and polymorphisms in CIN and MIN pathways implicated in CRC.
Detailed the genetic underpinnings of CRC development through these instability pathways.

Conclusions:

Gene mutations and polymorphisms in CIN and MIN pathways are fundamental to colorectal cancer development.
Understanding these genetic alterations is vital for future CRC research and therapeutic strategies.