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Related Concept Videos

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Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
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Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

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Updated: May 11, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Acquired reactive perforating dermatosis.

Gunnar Wagner1, Michael Max Sachse

  • 1Department of Dermatology, Allergology, and Phlebology, Bremerhaven Reinkenheide Hospital, Germany. gunnar.wagner@klinikum-bremerhaven.de

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|May 31, 2013
PubMed
Summary
This summary is machine-generated.

Acquired reactive perforating dermatosis presents with itchy, crusted skin lesions. Treatment focuses on managing itch and underlying conditions, with options like steroids, retinoids, and UVB therapy.

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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Acquired reactive perforating dermatosis (ARPD) is a rare skin condition.
  • It is characterized by specific skin lesions and histopathological findings.

Purpose of the Study:

  • To describe the clinical and histopathological features of ARPD.
  • To discuss the unclear etiology and pathogenesis of ARPD.
  • To outline the multimodal treatment approach for ARPD.

Main Methods:

  • Clinical observation of patient presentation.
  • Histopathological examination of skin biopsies.
  • Review of associated conditions and treatment outcomes.

Main Results:

  • ARPD presents with umbilicated, erythematous papules/plaques with crusts.
  • Histopathology reveals epidermal ulceration with transepidermal elimination of degenerated collagen.
  • Pruritus and skin trauma are key pathogenic factors, potentially involving genetic predisposition.

Conclusions:

  • ARPD pathogenesis is multifactorial, involving trauma, pruritus, and possibly genetics.
  • Treatment requires addressing underlying diseases and controlling pruritus.
  • Established treatments include systemic steroids, retinoids, UVB phototherapy, and potentially allopurinol.