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Related Concept Videos

Cross-Sectional Research01:50

Cross-Sectional Research

In cross-sectional research, a researcher compares multiple segments of the population at the same time. If they were interested in people's dietary habits, the researcher might directly compare different groups of people by age. Instead of following a group of people for 20 years to see how their dietary habits changed from decade to decade, the researcher would study a group of 20-year-old individuals and compare them to a group of 30-year-old individuals and a group of 40-year-old...
Interpreting ¹H NMR Signal Splitting: The (n + 1) Rule01:10

Interpreting ¹H NMR Signal Splitting: The (n + 1) Rule

In the AX proton spin system, proton A can sense the two spin states of a coupled proton X, resulting in a doublet NMR signal with two peaks of equal (1:1) intensity. When proton A is coupled to two equivalent protons (AX2 spin system), the spin states of each X can be aligned with or against the external field, creating three possible scenarios. This results in a 1:2:1  triplet signal, where the central peak corresponds to the chemical shift of A and is twice as large or intense as the others.
Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
Ethics in Research01:56

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
¹H NMR: Complex Splitting01:13

¹H NMR: Complex Splitting

A proton M that is coupled to a proton X results in doublet signals for M. However, NMR-active nuclei can be simultaneously coupled to more than one nonequivalent nucleus. When M is coupled to a second proton A, such as in styrene oxide, each peak in the doublet is split into another doublet.
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied first.
¹H NMR Signal Multiplicity: Splitting Patterns01:13

¹H NMR Signal Multiplicity: Splitting Patterns

When protons A and X are coupled, their nuclear spin energy levels are slightly modified. This is because the energy required to excite proton A to a spin state parallel to proton X is slightly different from the energy required for it to become anti-parallel to spin X. Consequently, there are two possible excitation frequencies for A (A1 and A2), depending on the spin state of X, and vice versa. The mutual nature of coupling implies that the difference between frequencies A1 and A2, indicated...

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Split-BioID — Proteomic Analysis of Context-specific Protein Complexes in Their Native Cellular Environment
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The SPLIT research agenda 2013.

Estella M Alonso1, Vicky L Ng, Ravinder Anand

  • 1Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. ealonso@luriechildrens.org

Pediatric Transplantation
|May 31, 2013
PubMed
Summary
This summary is machine-generated.

This review highlights key clinical research priorities in pediatric liver transplantation. It emphasizes areas where the Solutions for Progress in Liver Transplantation (SPLIT) infrastructure and data repository can advance patient care.

Keywords:
health outcomesindicationslong-term resultsoutcomepediatric liver transplantation

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Area of Science:

  • Hepatology
  • Pediatric Transplantation
  • Clinical Research

Background:

  • Pediatric liver transplantation is a complex field with ongoing research needs.
  • The Solutions for Progress in Liver Transplantation (SPLIT) initiative provides a collaborative platform and data repository.
  • Identifying research priorities is crucial for advancing the field.

Purpose of the Study:

  • To review current active clinical research in pediatric liver transplantation.
  • To identify research areas that would benefit from the SPLIT infrastructure and data repository.
  • To highlight high-impact research priorities for the SPLIT collaborative.

Main Methods:

  • A review of active clinical research in pediatric liver transplantation.
  • Solicitation of research ideas from the SPLIT Research Committee members.
  • Drafting of sections by committee members with relevant expertise.

Main Results:

  • Identified key areas for clinical research in pediatric liver transplantation.
  • Emphasized the potential of the SPLIT infrastructure and data repository to support these studies.
  • Prioritized research avenues with significant potential impact.

Conclusions:

  • The SPLIT collaborative is well-positioned to advance pediatric liver transplantation research.
  • Focusing on identified priorities can lead to significant improvements in patient outcomes.
  • Continued collaboration and data sharing are essential for progress.