[Wnt inhibitors and the suppression of bone formation in multiple myeloma]

In bone destructive lesions in multiple myeloma (MM) , enhanced bone resorption is accompanied by impaired bone formation and mineralization. The overproduction of inhibitors for the canonical Wingless-type (Wnt) signaling pathway, including DKK-1, sFRP-2 and sclerostin, significantly contributes to the suppression of osteoblastogenesis and bone formation in MM. However, the source of these Wnt inhibitors and the mechanisms of their aberrant production as well as their roles in tumor growth and osteoclastogenesis in MM bone lesions still remain obscure. Better understanding of the role of the Wnt pathway in the pathogenesis of MM may offer an effective therapeutic approach in MM.