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Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
Published on: July 8, 2020
Immunoglobulin A nephropathy: a review of current literature on emerging pathophysiology
Unnikrishnan Pillai1, Krishna Balabhadraputani, Zeenat Bhat
1Division of Nephrology (UP, ZB) and Department of Internal Medicine (KB), Wayne State University, Detroit, Michigan.
Abstract:
Immunoglobulin (Ig) A nephropathy is one of the most common causes of glomerulonephritis worldwide. Its prognosis can be totally different in various patient populations, ranging from asymptomatic slow progression to end-stage renal disease in as much as 40% of patients in few months to years. This disease process can be idiopathic, or it can be associated with a variety of disease processes. Various risk stratification scoring systems are available, which can predict the long-term outcome. New evidences are also emerging that IgA nephropathy is an autoimmune disease with a known antigen, galactose-deficient IgA1, which can elicit an autoantibody response and formation of immune complexes that are deposited in the mesangium.
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