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Updated: May 11, 2026

High-throughput Screening for Protein-based Inheritance in S. cerevisiae
Published on: August 8, 2017
A bioinformatics method for identifying Q/N-rich prion-like domains in proteins
Eric D Ross1, Kyle S Maclea, Charles Anderson
1Department of Biochemistry, Colorado State University, Fort Collins, CO, USA.
Abstract:
Numerous proteins contain domains that are enriched in glutamine and asparagine residues, and aggregation of some of these proteins has been linked to both prion formation in yeast and a number of human diseases. Unfortunately, predicting whether a given glutamine/asparagine-rich protein will aggregate has proven difficult. Here we describe a recently developed algorithm designed to predict the aggregation propensity of glutamine/asparagine-rich proteins. We discuss the basis for the algorithm, its limitations, and usage of recently developed online and downloadable versions of the algorithm.
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