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Related Experiment Videos

Metabolic changes during the normal menstrual cycle: a longitudinal study.

A M Lebech1, A Kjaer, P E Lebech

  • 1Department of Gynecology and Obstetrics, Frederiksberg Hospital, Copenhagen, Denmark.

American Journal of Obstetrics and Gynecology
|July 1, 1990
PubMed
Summary
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This study found no significant changes in lipids or lipoproteins during the menstrual cycle. However, fibrinogen levels increased in the luteal phase, potentially due to progesterone.

Area of Science:

  • Reproductive Endocrinology
  • Clinical Biochemistry
  • Hemostasis

Background:

  • Sex hormones fluctuate throughout the menstrual cycle.
  • These hormonal changes may influence metabolic and hemostatic processes.
  • Understanding these effects is crucial for interpreting clinical data and developing therapies.

Purpose of the Study:

  • To investigate the impact of the menstrual cycle on lipid metabolism and coagulation.
  • To determine if sex hormone fluctuations affect lipid profiles and key coagulation factors.
  • To assess the influence of sampling timing on these measurements.

Main Methods:

  • Studied 37 women, collecting blood samples during the follicular, midcycle, and luteal phases.
  • Ensured basal conditions by sampling in the morning while subjects were resting.

Related Experiment Videos

  • Analyzed lipids, lipoproteins, antithrombin III, factor VII, and fibrinogen levels.
  • Main Results:

    • No significant changes were observed in lipids and lipoproteins across the menstrual cycle phases.
    • Antithrombin III and factor VII levels remained constant throughout the cycle.
    • Fibrinogen levels increased during the luteal phase, correlating positively with progesterone concentrations.

    Conclusions:

    • Optimal study conditions reveal no menstrual cycle-related changes in lipids and lipoproteins.
    • Sampling day has minor importance for lipid/lipoprotein studies, including oral contraceptive trials.
    • Menstrual cycle phase is important for investigating certain coagulation parameters, particularly fibrinogen.