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Modafinil-induced Fixed Drug Eruption.

Girish Vasant Gaikwad¹, Chetali Vijay Dhuri

¹Department of Pharmacology, Topiwala National Medical College and BYL Nair Hospital, Mumbai Central, Mumbai, Maharashtra, India.

Indian Journal of Psychological Medicine

|June 1, 2013

Summary

This summary is machine-generated.

Modafinil, a wakefulness-promoting drug, can rarely cause severe skin reactions like fixed drug eruption. This case report links a single modafinil dose to this serious adverse drug event.

Keywords:

Adverse drug reaction fixed drug eruption modafinil

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Published on: April 23, 2019

Area of Science:

Pharmacology
Dermatology
Clinical Neurology

Background:

Modafinil is a commonly prescribed stimulant for promoting wakefulness.
While generally safe, it carries a risk of uncommon but severe dermatologic reactions.
Awareness of potential adverse drug events is crucial for patient safety.

Observation:

A patient developed a fixed drug eruption following a single dose of modafinil.
The reaction presented as a significant dermatologic side effect.
Diagnostic assessment utilized the Naranjo scale to evaluate causality.

Findings:

The Naranjo scale score of five indicated a probable causal link between modafinil and the adverse drug event.
Fixed drug eruption is a serious, albeit rare, dermatologic reaction to medications.
This case underscores the potential for modafinil to trigger severe cutaneous adverse reactions.

Implications:

Healthcare providers should maintain vigilance for dermatologic side effects in patients using modafinil.
Early recognition and management of drug-induced skin reactions are essential.
Further research may be warranted to understand the mechanisms of modafinil-induced dermatologic reactions.