Related Experiment Video
Updated: May 10, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
4-(2H-1,3-Benzodioxol-5-yl)-1-(4-methyl-phenyl)-1H-pyrazol-5-amine
Nilesh N Gajera1, Mukesh C Patel, Mukesh M Jotani
1P.S. Science and H.D. Patel Arts College, S.V. Campus, Kadi, Gujarat 382 715, India.
Abstract:
In the title compound, C17H15N3O2, two independent mol-ecules (A and B) comprise the asymmetric unit. The major conformational difference arises in the relative orientation of the pyrazole ring amine and dioxole substituents which are anti in A and syn in B. The five-membered dioxole ring in each mol-ecule has an envelope conformation with the methyl-ene C atom as the flap. The mean plane through the benzodioxole and benzene groups make dihedral angles of 31.67 (8) and 68.22 (9)°, respectively, with the pyrazole ring in A; the equivalent values for B are 47.18 (7) and 49.08 (9)°. In the crystal, supra-molecular zigzag chains along the b-axis direction arise as a result of N-H⋯N hydrogen bonding. These are consolidated into supra-molecular double chains via C-H⋯O and C-H⋯π inter-actions.
Related Concept Videos
Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...
Nomenclature of Aryl and Heterocyclic Amines
Diazonium Group Substitution: –OH and –H
Basicity of Heterocyclic Aromatic Amines
Five-Membered Heterocyclic Aromatic Compounds: Overview
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
