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Updated: May 10, 2026
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Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
Nitric oxide in asthma physiopathology
Carla M Prado1, Mílton A Martins, Iolanda F L C Tibério
1Department of Medicine, School of Medicine, University of São Paulo, 04023-900 São Paulo, SP, Brazil ; Departmento de Ciências Biológicas, Universidade Federal de São Paulo, 04301-012, Diadema, SP, Brazil.
ISRN Allergy
|June 1, 2013
Summary
Nitric oxide (NO) plays a key role in asthma. Inhibiting inducible nitric oxide synthase (iNOS) may treat asthma by reducing airway inflammation and remodeling.
Area of Science:
- Pulmonary Medicine
- Immunology
- Biochemistry
Background:
- Asthma is a chronic airway disease involving inflammation and remodeling.
- Nitric oxide (NO), from constitutive and inducible enzymes, impacts asthma pathology.
- Increased inducible nitric oxide synthase (iNOS)-derived NO in asthma links to oxidative stress.
Purpose of the Study:
- To explore the pathophysiological role of NO, particularly from iNOS, in allergic asthma.
- To highlight the therapeutic potential of NO donors and iNOS/arginase inhibitors in asthma treatment.
Main Methods:
- Review of animal in vivo studies on iNOS inhibition.
- Analysis of the role of NO in asthma pathophysiology and airway remodeling.
- Evaluation of therapeutic strategies involving NO modulation.
Main Results:
- iNOS inhibition may modulate key features of asthma, including extracellular matrix remodeling.
- Elevated iNOS-derived NO can increase peroxynitrite, disrupting oxidant-antioxidant balance.
- Endogenous NO from constitutive enzymes might protect against lung remodeling.
Conclusions:
- NO, especially from iNOS, is central to allergic asthma mechanisms.
- NO donors and iNOS inhibitors show therapeutic promise for asthma.
- Combined therapies with corticosteroids may counteract airway remodeling in asthma.
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