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Related Experiment Video

Updated: May 10, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

A cytoprotective perspective on longevity regulation.

David E Shore¹, Gary Ruvkun

¹Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

Trends in Cell Biology

|June 4, 2013

Summary

This summary is machine-generated.

Lifespan extension mechanisms, like altered insulin/IGF-1 signaling, activate cytoprotective pathways. These pathways, including detoxification and proteostasis, are crucial for longevity across species and diverse triggers.

Keywords:

aging cytoprotection detoxification hormesis longevity stress

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Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

Area of Science:

Molecular Biology
Genetics
Aging Research

Background:

Lifespan extension is linked to disruptions in insulin/IGF-1 signaling, metabolism, translation, and feeding.
These pathways, despite functional differences, induce stress and damage buffering responses.

Purpose of the Study:

To explore effectors and upstream regulators of cytoprotective mechanisms in longevity programs.
To investigate the role of detoxification, innate immunity, proteostasis, and oxidative stress response in lifespan extension.

Main Methods:

Genetic analyses in Caenorhabditis elegans.
Examination of cytoprotective pathways activated by diverse longevity triggers.

Main Results:

Induction of cytoprotective pathways underpins longevity extension.
These effects are observed across functionally diverse triggers and species.
Cytoprotective pathways are coupled to cellular component surveillance.

Conclusions:

Cytoprotective mechanisms are conserved and essential for longevity.
These pathways have implications for responses to drugs, chemicals, and pathogens.
Longevity pathways are intertwined with cellular surveillance systems.