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A cytoprotective perspective on longevity regulation

David E Shore1, Gary Ruvkun

  • 1Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

Trends in Cell Biology
|June 4, 2013
PubMed

Insights

Lifespan extension mechanisms, like altered insulin/IGF-1 signaling, activate cytoprotective pathways. These pathways, including detoxification and proteostasis, are crucial for longevity across species and diverse triggers.

Area of Science:

  • Molecular Biology
  • Genetics
  • Aging Research

Background:

  • Lifespan extension is linked to disruptions in insulin/IGF-1 signaling, metabolism, translation, and feeding.
  • These pathways, despite functional differences, induce stress and damage buffering responses.

Purpose of the Study:

  • To explore effectors and upstream regulators of cytoprotective mechanisms in longevity programs.
  • To investigate the role of detoxification, innate immunity, proteostasis, and oxidative stress response in lifespan extension.

Main Methods:

  • Genetic analyses in Caenorhabditis elegans.
  • Examination of cytoprotective pathways activated by diverse longevity triggers.

Main Results:

  • Induction of cytoprotective pathways underpins longevity extension.
  • These effects are observed across functionally diverse triggers and species.
  • Cytoprotective pathways are coupled to cellular component surveillance.

Conclusions:

  • Cytoprotective mechanisms are conserved and essential for longevity.
  • These pathways have implications for responses to drugs, chemicals, and pathogens.
  • Longevity pathways are intertwined with cellular surveillance systems.
Keywords:
agingcytoprotectiondetoxificationhormesislongevitystress

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