Related Experiment Video
Updated: May 10, 2026

A Modified Precipitation Method to Isolate Urinary Exosomes
Published on: January 16, 2015
Urinary exosome miRNome analysis and its applications to salt sensitivity of blood pressure
John J Gildea1, Julia M Carlson1, Cynthia D Schoeffel2
1Department of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA.
Objectives:
To investigate microRNAs (miRNAs) in urinary exosomes and their association with an individual's blood pressure response to dietary salt intake.
Design And Methods:
Human urinary exosomal miRNome was examined by microarray.
Results:
Of 1898 probes tested, 194 miRNAs were found in all subjects tested. 45 miRNAs had significant associations with salt sensitivity or inverse salt sensitivity.
Conclusion:
The expression of 45 urinary exosomal miRNAs associates with an individual's blood pressure response to sodium.
Related Concept Videos
Overview of Exosomes
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Urine Studies II: Urine Culture and Sensitivity Test
Physiology of the Genitourinary System III: Urine Concentration and Dilution
Urine Studies I: Urinalysis
