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Relationship between aortic valve sclerosis and different vascular damage markers: an observational study

Levent Korkmaz1, Mustafa Tarık Ağaç, Ayça Ata Korkmaz

  • 1Clinic of Cardiology, Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Trabzon-Turkey. l.korkmaz@yahoo.com.

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|June 4, 2013
PubMed

Insights

Aortic valve sclerosis (AVS) is linked to increased intima-media thickness (IMT), suggesting it is a multifactorial condition. This study found IMT, not pulse-wave velocity (PWV), to be a key predictor of AVS.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Medical Diagnostics

Background:

  • Aortic valve sclerosis (AVS) shares potential links with atherosclerosis.
  • The exact relationship between AVS and atherosclerotic/nonatherosclerotic processes remains debated.

Purpose of the Study:

  • To investigate the association between aortic valve sclerosis (AVS) and atherosclerotic markers.
  • To determine if AVS is related to both atherosclerotic and nonatherosclerotic factors.

Main Methods:

  • Cross-sectional study comparing 60 AVS patients with 76 controls.
  • Applanation tonometry measured augmentation index and aortic pulse-wave velocity (PWV).
  • B-mode ultrasound assessed intima-media thickness (IMT); logistic regression identified predictors.

Main Results:

  • Intima-media thickness (IMT) was significantly higher in the AVS group (p<0.001).
  • Pulse-wave velocity (PWV) and augmentation index did not differ significantly between groups.
  • Intima-media thickness (IMT) and age were independent predictors of AVS (p=0.009 and p=0.013, respectively).

Conclusions:

  • Increased IMT in AVS patients suggests a link to atherosclerotic processes.
  • The lack of difference in PWV indicates AVS may involve nonatherosclerotic pathways.
  • AVS is likely a multifactorial condition influenced by both atherosclerotic and nonatherosclerotic factors.
Abstract

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