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Accelerated immunotherapy schedules.
1Dilley Allergy and Asthma Specialists LLP, 7835 I-10 West, San Antonio, TX 78230, USA. chriscalabs@aol.com
Current Allergy and Asthma Reports
|June 4, 2013
Summary
Accelerated immunotherapy, including cluster and rush schedules, offers faster build-up to maintenance doses. Recent studies confirm its safety across diverse patient groups and highlight immunological changes and risk factors.
Area of Science:
- Allergy and Immunology
- Immunotherapy Protocols
Background:
- Traditional immunotherapy involves slow build-up to allergen tolerance.
- Accelerated schedules, like cluster and rush immunotherapy, aim to shorten this induction phase.
Purpose of the Study:
- To provide an updated review of accelerated immunotherapy schedules.
- To synthesize recent evidence on the safety, efficacy, and immunological effects of cluster and rush immunotherapy.
Main Methods:
- Review of recent investigations and studies on accelerated immunotherapy.
- Analysis of data concerning safety in specific populations (atopic dermatitis, pediatric patients) and with allergen mixtures.
- Examination of novel allergen delivery methods (infusion pumps).
- Discussion of immunological changes and systemic reaction risk factors.
Main Results:
- Cluster immunotherapy involves sequential allergen injections over nonconsecutive days, reaching maintenance doses in 4-8 weeks.
- Rush immunotherapy administers higher doses at short intervals (15-60 min) over 1-3 days.
- Recent data support the safety of cluster schedules in atopic dermatitis, pediatric patients, and with inhalant allergen mixtures.
- Further insights into immunological alterations and systemic reaction risks associated with accelerated protocols are available.
Conclusions:
- Accelerated immunotherapy schedules (cluster and rush) are effective and safe options for allergen immunotherapy.
- Ongoing research continues to refine protocols, understand immunological responses, and minimize risks.
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