Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
Varicose Veins I: Introduction01:26

Varicose Veins I: Introduction

Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of GLP-1 receptor agonists and dual GLP-1/GIP receptor agonists in managing MALFD: a meta-analysis of randomized controlled trials.

BMC gastroenterology·2025
Same author

Unused medicine take-back programmes: a systematic review.

Journal of pharmaceutical policy and practice·2024
Same author

Strategies to enhance risk communication about medicines in Malaysia: a Delphi study among multinational experts.

BMC health services research·2024
Same author

Use of Biosimilars: A Systematic Review of Published Position Statements and Recommendations from Health Organisations and Societies.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2024
Same author

The use of technology in vaccine safety communication: A systematic review of randomised controlled trials.

Patient education and counseling·2023
Same author

Malaysian Hospital Pharmacists' Perspectives and Their Role in Promoting Biosimilar Prescribing: A Nationwide Survey.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2022

Related Experiment Video

Updated: May 10, 2026

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
08:05

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

Published on: December 9, 2022

Flavonoids for treating venous leg ulcers.

Christopher Scallon1, Sally E M Bell-Syer, Zoriah Aziz

  • 1Epsom, UK. chris.scallon@hotmail.co.uk.

The Cochrane Database of Systematic Reviews
|June 4, 2013
PubMed
Summary

Flavonoids may aid venous leg ulcer healing, but evidence quality is low. More rigorous trials are needed to confirm the benefits of Micronised Purified Flavonoid Fraction (MPFF) and hydroxyethylrutosides (HR) for chronic wound care.

Area of Science:

  • Vascular Medicine
  • Dermatology
  • Pharmacology

Background:

  • Venous leg ulcers represent a significant health burden, costing the UK's NHS approximately GBP 400 million annually.
  • Flavonoids, natural venotonic compounds, influence microcirculatory parameters relevant to venous leg ulcer pathophysiology.

Purpose of the Study:

  • To systematically evaluate the clinical effectiveness of flavonoid compounds in promoting the healing of venous leg ulcers.

Main Methods:

  • A comprehensive literature search was conducted in February 2013 across multiple databases, including Cochrane Wounds, CENTRAL, MEDLINE, EMBASE, and CINAHL.
  • Included were randomized controlled trials (RCTs) assessing flavonoid efficacy in adult venous leg ulcer healing, with no date or language restrictions.
  • Risk of bias assessment and data extraction were performed independently by two reviewers, with discrepancies resolved by a third author.

More Related Videos

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
09:50

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

Published on: August 14, 2019

Procedure for Human Saphenous Veins Ex Vivo Perfusion and External Reinforcement
09:50

Procedure for Human Saphenous Veins Ex Vivo Perfusion and External Reinforcement

Published on: October 1, 2014

Related Experiment Videos

Last Updated: May 10, 2026

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
08:05

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

Published on: December 9, 2022

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
09:50

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

Published on: August 14, 2019

Procedure for Human Saphenous Veins Ex Vivo Perfusion and External Reinforcement
09:50

Procedure for Human Saphenous Veins Ex Vivo Perfusion and External Reinforcement

Published on: October 1, 2014

Main Results:

  • Five trials (723 participants) using Micronised Purified Flavonoid Fraction (MPFF) showed a potential benefit in ulcer healing (RR 1.36), though the most rigorous trial found no significant effect (RR 0.94).
  • Four trials (279 participants) on hydroxyethylrutosides (HR) indicated a statistically significant improvement in healed ulcers (RR 1.70).
  • The overall quality of reporting for most trials was poor, with an unclear risk of bias, and potential for publication bias was noted.

Conclusions:

  • While aggregated data suggest flavonoids (MPFF and HR) may promote venous leg ulcer healing, these findings must be interpreted cautiously due to the poor quality and high risk of bias in most included studies.
  • The potential for publication bias further complicates the interpretation of the overall results.
  • Further high-quality, rigorously conducted RCTs are necessary to definitively establish the efficacy of flavonoids in venous leg ulcer treatment.