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Related Experiment Video

Updated: May 10, 2026

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos
11:25

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Published on: February 22, 2016

Morphogenetic analysis of peri-implantation development.

Mary C Wallingford1, Jesse R Angelo, Jesse Mager

  • 1Department of Bioengineering, University of Washington, Seattle, Washington, USA.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|June 4, 2013
PubMed
Summary

This study details molecular and morphogenetic events during mouse peri-implantation in vivo. Key transcription factor changes and cell behaviors during early development are revealed, offering insights into implantation processes.

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Area of Science:

  • Developmental Biology
  • Mammalian Embryogenesis
  • Reproductive Biology

Background:

  • Successful implantation is critical for placental mammal development.
  • Molecular and morphogenetic events of peri-implantation are largely unexplored.

Purpose of the Study:

  • To investigate molecular and morphogenetic changes during mouse peri-implantation in vivo.
  • To analyze key transcription factor expression and morphogenetic events during early embryonic development.

Main Methods:

  • Detailed morphological and immunohistochemical analysis of mouse embryos (E3.75-E5.25).
  • Examined expression of transcription factors (Sox2, Oct4, Nanog, Cdx2, Gata6, Sox17, Yy1).
  • Analyzed localization of ZO-1, Laminin, and E-Cadherin for morphogenetic changes.
Keywords:
Sox17implantationprimitive endodermuterine luminal epithelium

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Last Updated: May 10, 2026

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Published on: February 22, 2016

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Published on: June 12, 2020

Main Results:

  • Documented molecular and morphological changes in primitive endoderm cells during differentiation.
  • Identified tissue-specific expression patterns of GATA6.
  • Observed a distinct SOX17 expression pattern suggesting a role in uterine implantation site selection.

Conclusions:

  • Identified key morphogenetic landmarks for characterizing peri-implantation mutant phenotypes.
  • Enhanced understanding of peri-implantation development.
  • Provides a foundation for studying peri-implantation lethality in knockout models.