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Related Experiment Video

Updated: May 10, 2026

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

Coupled Particulate and Continuum Model for Nanoparticle Targeted Delivery.

Jifu Tan¹, Shunqiang Wang, Jie Yang

¹Department of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, PA, 18015.

Computers & Structures

|June 5, 2013

Summary

This summary is machine-generated.

This study presents a combined model to predict nanoparticle distribution in blood vessels. The model links molecular binding to nanoparticle adhesion, enabling faster evaluation of drug delivery efficiency.

Keywords:

Brownian dynamics adhesion kinetics convection-diffusion-reaction model nanoparticle particulate-continuum coupled model

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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

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Last Updated: May 10, 2026

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Area of Science:

Biomedical Engineering
Computational Biology
Nanotechnology

Background:

Nanoparticle (NP) distribution in vasculature is key for drug delivery efficiency.
Predicting NP transport requires understanding phenomena across multiple scales.

Purpose of the Study:

To develop a combined particulate and continuum model for NP transport and delivery.
To link molecular-level binding kinetics to macroscale NP distribution.

Main Methods:

Coupling ligand-receptor binding kinetics with Brownian dynamics for microscale NP binding.
Deriving an analytical formula for NP adhesion and detachment rates.
Integrating NP adhesion rates into a convection-diffusion-reaction model for macroscale transport.

Main Results:

The continuum model's binding results align well with the particulate model.
Investigated effects of shear rate, particle size, and vascular geometry on NP adhesion.
Analytical formula predictions showed good agreement with literature experimental data.

Conclusions:

The coupled model effectively links ligand-receptor dynamics to NP adhesion and macroscale delivery.
This model serves as a rapid prediction tool for NP distribution in complex vascular networks.