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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
Published on: August 15, 2019
The systems genetics resource: a web application to mine global data for complex disease traits.
Atila van Nas1, Calvin Pan, Leslie A Ingram-Drake
1Department of Human Genetics, University of California Los Angeles, Los Angeles, CA, USA.
Frontiers in Genetics
|June 5, 2013
Summary
The Systems Genetics Resource (SGR) is an open-access database linking genotypes to complex disease traits in humans and mice. It aids researchers in identifying genes and pathways for conditions like obesity and diabetes.
Area of Science:
- Genetics
- Bioinformatics
- Systems Biology
Background:
- Complex diseases result from interactions between multiple genes and environmental factors.
- Understanding these genetic underpinnings requires large-scale, integrated datasets.
- Existing resources may lack comprehensive genotype and phenotype data for both human and mouse models.
Purpose of the Study:
- To introduce the Systems Genetics Resource (SGR), a novel open-access web application and database.
- To provide researchers with genotypes and phenotypic data from human and mouse studies.
- To facilitate the study of genetic factors contributing to complex diseases.
Main Methods:
- Compilation of genotype and phenotype data from human and mouse studies.
- Inclusion of data from inbred strain crosses and the Hybrid Mouse Diversity Panel.
- Integration of intermediate phenotypes such as gene expression, metabolite, and protein levels.
- Development of a user-friendly web interface for data access and analysis.
Main Results:
- The SGR database contains extensive genotype and phenotype data for human and mouse studies.
- Pre-computed tables of genetic loci and phenotype correlations are available.
- Detailed protocols for all included studies are accessible via the website.
- The resource supports research into complex traits including obesity, diabetes, and cardiovascular diseases.
Conclusions:
- The Systems Genetics Resource (SGR) provides a valuable, integrated platform for systems genetics research.
- It enables researchers to investigate the genetic architecture of complex diseases more effectively.
- Future expansion will include data on additional complex traits and conditions.
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