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Updated: May 10, 2026

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
Medications for substance use disorders
Antoine B Douaihy1, Thomas M Kelly, Carl Sullivan
1Department of Psychiatry, Western Psychiatric Institute & Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. douaihya@upmc.edu
Abstract:
In this article, the authors briefly review the pharmacotherapeutic agents that are currently available for the treatment of substance use disorders. Nicotine replacement therapies are most effective for tobacco cessation. Naltrexone, acamprosate, and disulfiram are effective for reducing alcohol use. The most effective pharmacotherapies for opiate use disorders are agonist therapies, including methadone and buprenorphine. The authors also examine recent advances in medication development for other substance use disorders such as stimulant addiction. The role of medication adherence and behavioral treatments and the integration of behavioral and pharmacotherapeutic interventions are also discussed.
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