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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Introduction to Biological Bases of Psychology01:30

Introduction to Biological Bases of Psychology

Biopsychology serves as a vital bridge connecting the intricate domains of biology and psychology, shedding light on how biological systems influence psychological phenomena. This field scrutinizes the biological substrates of behavior and mental processes, emphasizing the nervous system along with the roles of neurotransmitters, hormones, and genetics. It also incorporates evolutionary perspectives to explain the adaptive nature of mental functions.
The nervous system, the cornerstone of...
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

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Related Experiment Video

Updated: May 10, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

Epigenetic layers and players underlying neurodevelopment.

Janine M LaSalle1, Weston T Powell, Dag H Yasui

  • 1Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California, Davis, CA, USA. jmlasalle@ucdavis.edu

Trends in Neurosciences
|June 5, 2013
PubMed
Summary
This summary is machine-generated.

Epigenetic mechanisms are crucial for brain development, influencing how environmental factors affect the early brain. Understanding these epigenetic layers is key to deciphering neurodevelopmental disorders.

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Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
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Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Related Experiment Videos

Last Updated: May 10, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Area of Science:

  • Neuroscience
  • Epigenetics
  • Developmental Biology

Background:

  • Epigenetic mechanisms provide regulatory information beyond DNA sequence.
  • These mechanisms are vital for complex brain development and long-term environmental effects.
  • Neuronal epigenetics are dynamic and change with transcriptional activity.

Purpose of the Study:

  • To summarize current understanding of dynamic epigenetic layers in neuronal development.
  • To highlight the role of epigenetics in neuronal maturation.

Main Methods:

  • Review of current research on epigenetic mechanisms.
  • Analysis of the dynamic methylome, chromatin proteome, noncoding RNAs, chromatin loops, and long-range interactions.

Main Results:

  • Epigenetic layers dynamically regulate neuronal development and maturation.
  • Genetic alterations in epigenetic regulators are linked to neurodevelopmental disorders.

Conclusions:

  • Epigenetic players and layers are critical for early brain transcriptional events.
  • Understanding these epigenetic mechanisms is essential for neurodevelopmental disorder research.