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Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice
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Hyperbaric oxygen-induced seizures cause a transient decrement in cognitive function.

L Domachevsky1, L Rachmany, Y Barak

  • 1Israel Naval Medical Institute, IDF Medical Corps, Box 89, Rambam Health Care Campus, PO Box 9602, 3109601 Haifa, Israel. liranura@gmail.com

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|June 5, 2013
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Summary

Hyperbaric oxygen-induced seizures caused temporary cognitive deficits in mice, impacting memory and anxiety. Some effects, like on the elevated plus maze, persisted longer, suggesting potential for lasting neurological impact.

Keywords:
ATACNSHBOatmospheres absolutebehavioral testscentral nervous systemconvulsionshyperbaric oxygenneurologic damageoxygen toxicity

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Area of Science:

  • Neuroscience
  • Hyperbaric Medicine

Background:

  • Hyperbaric oxygen-induced seizures are typically brief generalized tonic-clonic seizures.
  • Previous assumptions suggested no residual cognitive damage, but this lacked in-depth investigation.

Purpose of the Study:

  • To investigate the potential for behavioral and cognitive impairments following hyperbaric oxygen-induced seizures.
  • To assess the duration and nature of these potential deficits.

Main Methods:

  • Mice underwent hyperbaric oxygen exposure to induce seizures.
  • Cognitive function was evaluated using Y-maze, novel object recognition, elevated plus maze, and passive avoidance tasks.
  • Performance was assessed at 24 hours, 7 days, and 30 days post-seizure.

Main Results:

  • Transient impairments were observed in novel object recognition, Y-maze, and passive avoidance tasks.
  • Impairment in the elevated plus maze test persisted throughout the study period.
  • The onset and recovery times for deficits varied across different behavioral tests.

Conclusions:

  • Hyperbaric oxygen-induced seizures lead to transient cognitive and behavioral impairments in a mouse model.
  • The persistent deficit on the elevated plus maze warrants further investigation into potential permanent damage.
  • Findings necessitate careful consideration of hyperbaric oxygen protocols to balance therapeutic benefits with central nervous system oxygen toxicity risks.