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Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Synthesis, antibacterial and antifungal evaluation of novel 1,4-dihydropyridine derivatives
1Faculty of Science of Girls, King Khaled University, Abha, Saudi Arabia. hanaaabumelha@yahoo.com
Abstract:
3,5-Diacetyl-1,4-dihydro-2,4,6-trimethylpyridine (I) has been condensed with aromatic aldehydes to give the corresponding cinnamoyl derivatives IIa-e. the behavior of IIc, d towards thiourea, hydroxylamine hydrochloride, hydrazine hydrate and other bifunctional reagents has been investigated. The newly synthesized compounds were screened for their antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and as antifungal reagent. Among all the tested compounds, it was found that compounds IIIa and VIIa, b revealed better activity against the Gram-positive rather than the Gram-negative bacteria.
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