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Bile acids do not regulate the intestinal mucosal cholesterol synthesis: studies in the chronic bile duct-ureter
L N Castilho1, A M Sipahi, A Bettarello
1Gastroenterology Unit, Hospital das Clínicas (LIM), University of São Paulo Medical School, Brazil.
Abstract:
Control male Wistar rats with intact bile circulation, animals with a bile duct-right ureter fistula, and bile duct-right ureter fistula rats fed taurocholic acid (5.5 mg/day) were maintained on a cholesterol-free pellet diet and pulse labeled subcutaneously with radioactive cholesterol. Bile acid feeding did not interfere with the synthesis of cholesterol by the intestinal mucosa or by the whole body in spite of markedly lowering the production of bile acids. Of the total fecal cholesterol mass in bile fistula animals roughly 25% originated from plasma filtration and 75% was ascribed to local mucosal cholesterol synthesis.