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Related Experiment Video

Updated: May 10, 2026

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

Pseudotemporal ictal patterns compared with mesial and neocortical temporal ictal patterns.

Sherif A Elwan1, Norman K So, Rei Enatsu

  • 1Epilepsy Center, Cleveland Clinic, Cleveland, Ohio 44195, USA.

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
|June 5, 2013
PubMed
Summary

Differentiating falsely localizing pseudotemporal ictal electroencephalogram (EEG) patterns from true temporal lobe epilepsy is challenging. Morphological analysis and source localization cannot reliably distinguish these patterns, indicating they are indistinguishable.

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Area of Science:

  • Neuroscience
  • Epileptology
  • Clinical Neurophysiology

Background:

  • Distinguishing pseudotemporal ictal patterns from true temporal lobe epilepsy (TLE) is crucial for accurate diagnosis and treatment.
  • Falsely localizing patterns can complicate surgical planning and outcome prediction in epilepsy patients.

Purpose of the Study:

  • To investigate the electroencephalogram (EEG) characteristics of pseudotemporal ictal patterns (PT) and compare them with mesial temporal epilepsy (MTLE) due to hippocampal sclerosis (HS) and neocortical temporal epilepsy (NT).
  • To determine if ictal EEG patterns and source localization can differentiate PT from true TLE.

Main Methods:

  • Retrospective analysis of 33 epilepsy surgery patients with favorable outcomes (Engel I).
  • Categorization into three groups: PT (10 patients, 37 seizures), HS (12 patients, 45 seizures), and NT (11 patients, 41 seizures).

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Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns
09:42

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns

Published on: May 12, 2019

Related Experiment Videos

Last Updated: May 10, 2026

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns
09:42

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns

Published on: May 12, 2019

  • Visual analysis of ictal EEGs and source localization (BESA 5.1); comparison of interictal discharge topographies.

    • Main Results:

    • Ictal patterns and locations showed overlap across all groups.
    • Initial onset patterns in NT were less likely to localize to a single temporal region (P < 0.008).
    • Rhythmic temporal theta was more frequent in HS than NT (P < 0.001); PT seizures were more likely to spread contralaterally (P < 0.05).
    • Source analysis and interictal discharge topography failed to differentiate the groups.

    Conclusions:

    • Pseudotemporal ictal patterns are morphologically indistinguishable from true temporal ictal patterns.
    • Rhythmic theta patterns, while more common in HS, can originate from extratemporal propagation.
    • Current EEG analysis methods are insufficient to reliably differentiate PT from true TLE.