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A medication diary-book for pediatric patients with acute lymphoblastic leukemia in Indonesia

Mei N Sitaresmi1, Saskia Mostert, Chad M Gundy

  • 1Department of Pediatrics, Dr Sardjito Hospital, Yogyakarta, Indonesia.

Pediatric Blood & Cancer
|June 5, 2013
PubMed

Insights

A medication diary improved event-free survival for children with acute lymphoblastic leukemia (ALL) in Indonesia, especially when mothers had higher education. This tool may enhance outcomes in resource-limited settings.

Area of Science:

  • Pediatric Oncology
  • Hematology
  • Public Health

Background:

  • Event-free survival (EFS) for pediatric acute lymphoblastic leukemia (ALL) in Yogyakarta, Indonesia was critically low at 20%.
  • Addressing low survival rates in childhood ALL is a significant challenge, particularly in resource-limited settings.

Purpose of the Study:

  • To evaluate the effectiveness of a medication diary-book intervention on the treatment outcomes of childhood ALL.
  • To assess the impact of the diary on event-free survival (EFS) in pediatric ALL patients.

Main Methods:

  • A randomized controlled trial involving 109 pediatric ALL patients in Yogyakarta, Indonesia.
  • Intervention group received a medication diary alongside standard care (parental education, donated chemotherapy); control group received standard care only.
  • Event-free survival (EFS) at 3 years was the primary outcome measure.

Main Results:

  • Pediatric ALL patients with highly educated mothers showed significantly improved 3-year EFS in the intervention group (62%) compared to the control group (29%, P=0.04).
  • No significant difference in 3-year EFS was observed between intervention (26%) and control (18%) groups for patients with less educated mothers (P=0.86).

Conclusions:

  • A medication diary-book intervention shows potential to improve survival for pediatric ALL patients in resource-limited settings.
  • The intervention's effectiveness appears particularly pronounced in children whose mothers have higher educational attainment.
Abstract

Keywords:
childhood acute lymphoblastic leukemiamedication diary-booktreatment outcome

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