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Related Concept Videos

Short-distance Transport of Resources02:12

Short-distance Transport of Resources

Short-distance transport refers to transport that occurs over a distance of just 2-3 cells, crossing the plasma membrane in the process. Small uncharged molecules, such as oxygen, carbon dioxide, and water, can diffuse across the plasma membrane on their own. In contrast, ions and larger molecules require the assistance of transport proteins due to their charge or size. Transport across membranes also occurs within individual cells, playing a variety of essential roles for the plant as a whole.
The Significance of Membrane Transport01:44

The Significance of Membrane Transport

The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
Carrier-Mediated Transport01:06

Carrier-Mediated Transport

Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
Nonlinear Pharmacokinetics: Role of Transporters01:27

Nonlinear Pharmacokinetics: Role of Transporters

A drug's nonlinear kinetics can be influenced by a diverse range of transporter proteins that serve as crucial players in drug distribution. These transporters, found within cells, can enhance or reduce local drug concentrations by facilitating the influx or efflux of drugs. For instance, the expression of xenobiotic transporters can be influenced by factors such as age and gender, potentially impacting the linearity of drug response.
Polymorphisms occurring in drug transporters can alter...
Reynolds Transport Theorem01:24

Reynolds Transport Theorem

The Reynolds transport theorem provides a framework to relate the time rate of change of an extensive property within a system to that in a control volume, which is crucial for analyzing fluid dynamics. Extensive properties, such as mass, velocity, acceleration, temperature, and momentum, can be expressed in terms of the mass of a fluid portion. These properties are called extensive because they depend on the system's size, while intensive properties are their corresponding values per unit mass.
Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time01:02

Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time

When drugs are administered extravascularly, a comprehensive evaluation through noncompartmental analysis becomes imperative. This analytical approach considers various parameters that play a crucial role in understanding the pharmacokinetics of these drugs.
One of the key parameters is the mean transit time (MTT), which refers to the total duration required for drug molecules to transit through the body. MTT is determined by calculating the ratio of the area under the moment curve to the area...

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Related Experiment Videos

Insights into capacity-constrained optimal transport.

Jonathan Korman1, Robert J McCann

  • 1Department of Mathematics, University of Toronto, Toronto, ON, Canada M5S 2E4. jkorman@math.toronto.edu

Proceedings of the National Academy of Sciences of the United States of America
|June 5, 2013
PubMed
Summary
This summary is machine-generated.

Researchers found an unexpected symmetry in a variant of the optimal transportation problem. This symmetry allows for explicit solutions in multiple dimensions, building on prior work on existence and uniqueness.

Keywords:
Monge–Kantorovich masscouplingfree boundaryinfinite dimensional linear programmingresource allocation

Related Experiment Videos

Area of Science:

  • Mathematics
  • Probability and Statistics
  • Optimization Theory

Background:

  • The classical optimal transportation problem seeks the cheapest way to move 'mass' between distributions.
  • A variant involves finding an optimal joint measure within a set of measures sharing fixed marginals and bounded by a given density.
  • Prior work by Korman and McCann established the existence and uniqueness of solutions for this variant.

Purpose of the Study:

  • To explore an unexpected symmetry within the constrained optimal transportation problem.
  • To derive explicit solutions for this problem in two or more dimensions.
  • To connect findings with one-dimensional simulations and theoretical developments in feasible set analysis.

Main Methods:

  • Leveraging an identified symmetry in the optimal transportation problem variant.
  • Developing explicit examples inspired by one-dimensional simulations exhibiting singularities and topology.
  • Utilizing the identification of extreme points in the feasible set.
  • Employing an approach to uniqueness based on constructing feasible perturbations.

Main Results:

  • An unexpected symmetry was discovered in the optimal transportation problem with a density constraint.
  • This symmetry facilitates the derivation of explicit solutions in dimensions two and higher.
  • The study provides concrete examples of optimal transport plans under these specific constraints.

Conclusions:

  • The identified symmetry offers a powerful new tool for solving constrained optimal transportation problems.
  • Explicit solutions are now attainable in higher dimensions, expanding the applicability of the theory.
  • The findings bridge theoretical advancements with insights from numerical simulations and feasible set characterization.