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Updated: May 10, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Immunotherapy with artificial adjuvant vector cells: Harnessing both arms of the immune response
Shin-Ichiro Fujii1, Kanako Shimizu
1Research Unit for Cellular Immunotherapy; The Institute of Physical and Chemical Research (RIKEN); Research Center for Allergy and Immunology (RCAI); Yokohama, Japan.
Abstract:
Both innate and adaptive immunity underpin cancer immunosurveillance. To stimulate both these arms of the immune system, we used allogeneic cells loaded with natural killer T (NKT) cell ligands and expressing tumor-associated antigens, resulting in NKT cell activation, dendritic-cell maturation and ultimately in the elicitation of adaptive T-cell responses. This approach holds great promise for the development of novel anticancer immunotherapies.
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