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09:15
Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
Mimotope vaccine efficacy gets a "boost" from native tumor antigens
Jonathan D Buhrman1, Jill E Slansky
1Integrated Department of Immunology; University of Colorado School of Medicine; Denver CO, USA.
Oncoimmunology
|June 5, 2013
Abstract:
Tumor-associated antigen (TAA)-targeting mimotope peptides exert more prominent immunostimulatory functions than unmodified TAAs, with the caveat that some T-cell clones exhibit a relatively low affinity for TAAs. Combining mimotope-based vaccines with native TAAs in a prime-boost setting significantly improves antitumor immunity.
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01:30Cancer Vaccines
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01:51Vaccinations
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