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Updated: May 10, 2026

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
Published on: February 14, 2025
NK cells from malignant pleural effusions are potent antitumor effectors: A clue for adoptive immunotherapy?
Paola Vacca1, Stefania Martini, Maria C Mingari
1Department of Experimental Medicine and Center of Excellence for Biomedical Research; University of Genova; Genova Italy.
Abstract:
Natural killer (NK) cells exert potent antitumor activity. However, NK cells infiltrating solid tumors are severely impaired in their function. Remarkably, NK cells isolated from malignant pleural effusions kill very efficiently tumor cells upon exposure to interleukin-2, offering an important clue for the development of novel approaches for tumor immunotherapy.
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