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Updated: May 10, 2026

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
Published on: February 14, 2025
Toward the next generation of NK cell-based adoptive cancer immunotherapy
Jing Ni1, Matthias Miller, Ana Stojanovic
1German Cancer Research Center (DKFZ); Junior Research Group Innate Immunity; Heidelberg, Germany.
Abstract:
The adoptive transfer of interleukin (IL)-2-expanded natural killer (NK) cells has provided unsatisfactory clinical benefits to patients affected by solid tumors. Our study demonstrates that the activation of NK cells with IL-12/IL-15/IL-18 prior to transfer into tumor-bearing mice is critical for obtaining high recovery rates, effector functions in vivo and tumor regression.
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