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Related Concept Videos

Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic sinusitis...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

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Updated: May 10, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
05:56

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

Cystic fibrosis.

A E Leitch1, H C Rodgers

  • 1Western General Hospital, Edinburgh, UK.

The Journal of the Royal College of Physicians of Edinburgh
|June 5, 2013
PubMed
Summary
This summary is machine-generated.

Adult cystic fibrosis (CF) patient numbers are rising, increasing their presence in diverse hospital settings. Early contact and structured management are crucial for optimal care of these patients.

Keywords:
CF servicesCystic fibrosisbronchiectasislung transplantationmanagement

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Cystic Fibrosis Aggregate Biofilm Model to Study Infection-relevant Gene Expression
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Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
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Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

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Last Updated: May 10, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
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Cystic Fibrosis Aggregate Biofilm Model to Study Infection-relevant Gene Expression
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Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
08:00

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

Published on: April 11, 2018

Area of Science:

  • Pulmonology
  • Internal Medicine
  • Genetics

Background:

  • Increasing life expectancy in cystic fibrosis (CF) patients leads to a growing adult population.
  • Adult CF patients are now more prevalent than pediatric patients.
  • Improved survival necessitates managing CF patients across various non-specialist hospital settings.

Purpose of the Study:

  • To highlight the increasing prevalence of adult cystic fibrosis patients.
  • To emphasize the need for a structured approach to CF patient assessment and management in general hospital settings.
  • To encourage early communication between CF units and other hospital departments.

Main Methods:

  • Literature review on adult CF patient demographics and care challenges.
  • Analysis of current hospital admission trends for CF patients.
  • Development of a framework for multidisciplinary CF care.

Main Results:

  • Adult CF patients represent a significant and growing demographic.
  • CF patients require management in diverse clinical areas such as fertility, GI, diabetes, and surgical wards.
  • Ad-hoc management can lead to suboptimal outcomes.

Conclusions:

  • A proactive and structured approach to managing adult CF patients is essential.
  • Early engagement with specialized CF teams improves patient outcomes.
  • Healthcare providers in all settings must be prepared for the complexities of adult CF care.