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Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
Protein-protein interactions as druggable targets: recent technological advances
Alicia P Higueruelo1, Harry Jubb, Tom L Blundell
1Department of Biochemistry, University of Cambridge, Cambridge CB1 2GA, UK.
Current Opinion in Pharmacology
|June 6, 2013
Summary
Discovering drugs targeting protein-protein interactions (PPI) is challenging. This review explores novel strategies like fragment-based methods and stapled peptides to overcome these hurdles in drug discovery.
Area of Science:
- Drug discovery and medicinal chemistry
- Molecular biology and biochemistry
Background:
- Classical drug discovery methods struggle with protein-protein interactions (PPI).
- Despite challenges, PPI are increasingly recognized as viable drug targets.
- The field of PPI drug discovery is rapidly advancing.
Purpose of the Study:
- To review emerging strategies for targeting protein-protein interactions (PPI).
- To highlight innovative approaches in PPI drug discovery.
Main Methods:
- Fragment-based drug discovery to explore chemical space.
- Stapled peptides for modulating intracellular PPI.
- Alternative inhibition strategies beyond competitive assays.
- Antibody-mediated approaches to facilitate small molecule discovery for PPI.
Main Results:
- New methods demonstrate feasibility of targeting PPI.
- Fragment-based approaches effectively probe PPI chemical space.
- Stapled peptides offer a way to regulate intracellular PPI.
- Antibodies can aid small molecule development for PPI targets.
Conclusions:
- Novel approaches are crucial for successful PPI drug discovery.
- The development of new strategies is accelerating progress in targeting PPI.
- PPI represent a promising frontier for future therapeutics.
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