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Related Experiment Video

Updated: May 10, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Interactions between the lateral habenula and the hippocampus: implication for spatial memory processes.

Romain Goutagny¹, Michael Loureiro, Jesse Jackson

¹1] Laboratoire de Neurosciences Cognitives et Adaptatives, UMR7364, Centre National de la Recherche Scientifique (CNRS), Strasbourg, France [2] Faculté de Psychologie, Université de Strasbourg, Strasbourg, France.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology

|June 6, 2013

Summary

This summary is machine-generated.

The lateral habenula (LHb) interacts with the hippocampus, influencing theta oscillations and spatial memory. This study reveals a functional connection crucial for hippocampus-dependent memory processing.

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Area of Science:

Neuroscience
Systems Neuroscience

Background:

The lateral habenula (LHb) influences midbrain monoaminergic nuclei and is involved in behavioral strategy selection.
Emerging evidence suggests a potential role for the LHb in hippocampus-dependent memory, but its interaction with the dorsal hippocampus (dHPC) remains unclear.

Purpose of the Study:

To investigate the functional interaction between the LHb and the dHPC.
To determine the role of the LHb in hippocampus-dependent spatial memory processes.

Main Methods:

Simultaneous electrophysiological recordings in the LHb and dHPC of rats.
Analysis of theta oscillations and their coherence between brain regions.
Reversible inactivation of the LHb.
Assessment of performance in a hippocampus-dependent spatial recognition task.

Main Results:

A subset of LHb cells phase-locked to hippocampal theta oscillations.
LHb exhibited spontaneous theta activity coherent with dHPC theta oscillations.
LHb inactivation modulated dHPC theta oscillations and impaired spatial recognition memory.
Increased LHb-dHPC coherence correlated positively with memory performance.

Conclusions:

The LHb functionally interacts with the dHPC.
The LHb plays a role in regulating dHPC theta oscillations and is involved in hippocampus-dependent spatial information processing.