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Related Experiment Video

Updated: Jan 16, 2026

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus

Published on: September 9, 2020

Predictive coding of reward in the hippocampus.

Mohammad Yaghoubi^1,2, M Ganesh Kumar^3,4,5, Andres Nieto-Posadas⁶

¹Douglas Hospital Research Center, McGill University, Montreal, Quebec, Canada. mohammad.yaghoubi@mail.mcgill.ca.

|January 14, 2026

Summary

The brain learns to predict future rewards by updating hippocampal representations. Experience shifts neural activity to anticipate rewards, crucial for learning.

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Last Updated: Jan 16, 2026

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus

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Published on: September 9, 2020

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Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

Area of Science:

Neuroscience
Cognitive Science
Computational Neuroscience

Background:

Anticipating future outcomes is a fundamental brain function.
The hippocampus forms spatial maps, but its role in reward processing is debated.
How reward representation evolves with experience is unclear.

Purpose of the Study:

To investigate the evolution of hippocampal reward representation during learning.
To determine if hippocampal representations become predictive of reward over time.

Main Methods:

Tracking hippocampal neuronal activity in mice over weeks.
Analyzing population and single-cell activity during a reward-based task.
Utilizing a temporal difference model to simulate place fields.

Main Results:

Hippocampal representations become predictive of reward with extended experience.
Reward encoding and reward-tuned neurons decrease as mice gain experience.
Neural activity shifts from encoding rewards to representing preceding task features.

Conclusions:

Experience drives a reorganization of hippocampal activity to anticipate rewards.
The hippocampus dynamically updates its representations for predictive learning.
Findings highlight the role of the hippocampus in learning through outcome prediction.