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Achromic verrucous large cell acanthoma.

P Ambrojo1, A Aguilar, L Requena

  • 1Department of Dermatology, San Carlos Hospital, Complutense University, Madrid, Spain.

Journal of Cutaneous Pathology
|June 1, 1990
PubMed
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Large cell acanthoma, an epidermal neoplasm, is typically pigmented. This report details the first achromic (non-pigmented) case, challenging existing theories about its origin.

Area of Science:

  • Dermatology
  • Neoplastic skin conditions
  • Epidermal neoplasms

Background:

  • Large cell acanthoma (LCA) is an epidermal neoplasm with debated etiology.
  • Current theories suggest LCA may be a variant of solar lentigo.
  • LCA is typically characterized by hyperpigmentation.

Observation:

  • This study presents an unusual case of achromic (non-pigmented) large cell acanthoma.
  • The lesion was observed on the dorsum of the right hand in an 83-year-old female patient.
  • This presentation deviates from the common hyperpigmented manifestation of LCA.

Findings:

  • The achromic nature of this LCA case challenges the hypothesis that LCA is solely a solar lentigo with enlarged keratinocyte nuclei.
  • This finding suggests a broader spectrum of clinical presentations for large cell acanthoma.

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  • Histopathological examination would be crucial for definitive diagnosis and understanding the neoplastic process.

    • Implications:

    • This case expands the differential diagnosis for achromic epidermal lesions.
    • Further research is needed to fully elucidate the pathogenesis of large cell acanthoma.
    • Understanding variations in LCA presentation is important for accurate clinical diagnosis and management.