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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
Regulatory T cells in allogeneic stem cell transplantation
Maria Michael1, Avichai Shimoni, Arnon Nagler
1Hematology Division & Bone Marrow Transplantation, Chaim Sheba Medical Center, Sackler Medical School, Tel Aviv University, Tel Aviv 52621, Israel.
Regulatory T cells (Tregs) show promise for cell-based immunotherapy in transplantation. Enhancing Treg expansion technologies is key to their wider clinical use in managing immune responses.
Area of Science:
- Immunology
- Cellular Therapy
- Transplantation Science
Background:
- Cellular adoptive immunotherapy is a developing strategy for managing tumor immunity and alloresponses in clinical transplantation.
- Naturally arising CD4+CD25+Foxp3+ regulatory T cells (Tregs) are critical for immune regulation in autoimmunity and tumor immunity.
Purpose of the Study:
- To review current knowledge on regulatory T cell (Treg) biology.
- To explore the potential of Tregs for cell-based immunotherapy in allogeneic stem cell transplantation.
Main Methods:
- Review of preclinical models and early clinical studies.
- Analysis of Treg biology and expansion technologies.
Main Results:
- Preclinical data highlight the crucial role of Tregs in immune tolerance.
- Early clinical trials in allogeneic stem cell transplantation show encouraging results.
Conclusions:
- Tregs represent a promising cell-based immunotherapy approach for transplantation.
- Advancements in Treg expansion are essential for broad clinical application.
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