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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Related Experiment Video

Updated: May 10, 2026

Generation of Induced Pluripotent Stem Cell-Derived iTenocytes via Combined Scleraxis Overexpression and 2D Uniaxial Tension
04:48

Generation of Induced Pluripotent Stem Cell-Derived iTenocytes via Combined Scleraxis Overexpression and 2D Uniaxial Tension

Published on: March 1, 2024

Mesenchymal stem cell applications to tendon healing.

Salma Chaudhury1

  • 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK.

Muscles, Ligaments and Tendons Journal
|June 6, 2013
PubMed
Summary

Stem cells show promise for tendon repair by promoting new tissue formation instead of scar tissue. Further research is needed to confirm their safety and effectiveness for clinical use in tendon healing.

Keywords:
cytokinesregenerationrotator cuffstem celltendon

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Published on: December 9, 2015

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Orthopedic Research

Background:

  • Age-related changes diminish tendon regenerative capacity.
  • Tendon injuries often heal with weaker scar tissue, increasing re-injury risk.
  • Biological stimuli are being explored to enhance tendon repair.

Purpose of the Study:

  • To review in-vitro and in-vivo evidence on stem cell effects on tendon healing.
  • To assess the potential clinical applications of stem cells for tendon repair.
  • To evaluate stem cells as a therapeutic option for tendon regeneration.

Main Methods:

  • Literature review of in-vitro studies on stem cell-mediated tendon repair.
  • Analysis of in-vivo experimental data on stem cell therapies for tendons.
  • Examination of current research on stem cell mechanisms in tendon healing.

Main Results:

  • Stem cells offer potential to stimulate neotendon formation over scar tissue.
  • Evidence suggests stem cells can modulate the inflammatory and reparative response.
  • Further investigation is required to optimize stem cell application and efficacy.

Conclusions:

  • Stem cells represent a promising therapeutic strategy for improving tendon healing outcomes.
  • Clinical application requires further validation of safety and efficacy.
  • Future research should focus on stem cell types, delivery methods, and long-term effects.